CCMB scientists discover valuable application of secretagogin protein in fight against diabetes.

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Over 30 million people in India had been diagnosed with diabetes in 2018 and the prevalence rate increasing rapidly in 2019.
In this scenario, the scientists at CSIR- Centre for Cellular Research and Molecular Biology (CCMB) have findings about secratagogin (SCGN) protein which establish it as having therapeutic potential against diabetes.

Insulin secreted by pancreas regulates blood sugar levels in the body. According to scientists, various kinds of cellular stresses can affect the insulin structure and functions and ultimately leading to diabetes.

SCGN protein here has been identified in the report of CCMB with the abilities to bind to insulin and protect it from various stresses, increasing it's stability and adding to its action.

The team of scientists from CCMB included Yogendra Sharma, Radhika Khandelwal, and Amrutha Chidananda who have worked on demonstrating the said roles of SCGN protein while studying its calcium binding properties.

Scientists have identified clearance of excess insulin and reduction of fat mass upon the injection of SCGN in mice.

Treated animals also showed lower levels of harmful LDL cholesterol and lower lipid accumulation in liver cells according to the latest issue of the journal iScience.

Many neurodegenerative diseases like dementia and Alzheimer's are lead to by the formation of alpha-synuclein protein fibrils. In a study published in Biochemistry, Sharmas Group, SCGN has been discovered with having potential of preventing the formation these alpha-synuclein protein fibrils.

SCGN would soon become a diagnostic marker, and one should check its potential in diabetes management, Sharma said.

While studying calcium-binding properties of SCGN, CCMB scientists have discovered a novel function of this protein in diabetes biology, yet another example of how quality basic science can lead to valuable applications, Rakesh Mishra, Director, CCMB, said
 

With these exemplary findings, both the respective groups working on them believe that SCGN protein has a novel function in diabetes biology and management.



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