Intermittent fasting : Boost immunity , helps fight diabetes , cancer says NEJM study

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Meanwhile you gear yourselves up with your new year health resolutions , here's some exciting news from a latest research findings published in prestigious medical journal The New England Journal of Medicine on the impact of intermittent fasting on health. 

Abstaining from food for 16 to 18 hours a day could be key to treating a variety of health conditions -- even if you've got to train yourself to push past the hunger.

A review of past animal and human studies in The New England Journal of Medicine suggests that intermittent fasting can reduce blood pressure, aid in weight loss and improve longevity.

Intermittent fasting impairs energy metabolism in cancer cells, inhibiting their growth and rendering them susceptible to clinical treatments, the researchers said.

According to the New England Journal of Medicine (NEJM), intermittent fasting — going without food for long hours periodically every week, or avoiding food for fixed hours every day — could work wonders with obesity, diabetes and cardiovascular diseases.

And that’s not all, they say. It could also stagger the progress of cancer and help in diseases like asthma and multiple sclerosis.

“…intermittent-fasting interventions ameliorate obesity, insulin resistance, dyslipidemia (abnormal amount of lipids), hypertension, and inflammation. Intermittent fasting seems to confer health benefits to a greater extent than can be attributed just to a reduction in caloric intake,” researchers from the Johns Hopkins University School of Medicine reported in NEJM.


The report functions as a road map of sorts for physicians to prescribe fasting as a method of prevention or treatment for obesity, cancer, diabetes and heart disease.
Study author Mark Mattson, a professor of neuroscience at Johns Hopkins University, hones in on two types: Daily time-restricted feeding (eating 6-8 hours a day and fasting for 16-18 hours) and 5:2 intermittent fasting (fasting two days a week, usually capping a fasting day at 500 calories).


Because the research is relatively new, the report advises physicians to monitor their patients throughout intermittent fasting and gradually increase the duration and frequency of fasting to guide their transition.

How it works

Intermittent fasting has been studied in rodents and overweight adults to improve health across the spectrum, though it's not clear if those benefits are the result of weight loss.

Alternating between fasting and eating can improve cellular health, Mattson said, most likely by triggering metabolic switching. In metabolic switching, cells use up their fuel stores and convert fat to energy -- "flipping a switch" from fat-storing to fat-saving.

The benefits

Findings on intermittent fasting range in the diet's effectiveness, but some studies in animals and humans have linked the practice to longer lives, healthier hearts and improved cognition.

The article points to the residents of Okinawa,known for their extreme longevity and low-calorie, nutrient-rich diet. Their intermittent fasting might contribute to their life spans and keep obesity at bay, the authors posited.

Intermittent fasting is thought to improve insulin resistance, which can stabilize blood sugar levels. Findings from a small 2018 study found that three men with type 2 diabetes, also known as adult-onset diabetes, were able to stop taking insulin after losing weight from intermittent fasting -- findings that clash with the widely-held belief that diabetes is incurable.

A previous study (that Mattson co-authored) showed the switch can increase resistance to stress by optimizing brain function and neuroplasticity, or the brain's ability to adapt to develop throughout one's life. And older adults who were put on a restricted-calorie diet showed improved verbal memory compared to two other groups who hadn't fasted, a 2009 study found.

Physical function even improved for some patients. A study of young men who fasted every day for 16 hours lost fat and retained muscle while resistance training for two months.

The challenges

The long-term effects of intermittent fasting require more research that isn't available yet, and the studies that do exist are narrow. The clinical trials focused on overweight young and middle-age adults, so the benefits and safety can't be generalized to other groups, the authors said. Moreover considering the geographical impact of diabetes in different parts of world , more larger trials will be required to be carried out before any specific conclusion is made. 





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